At our site in Aspen Oss, the Netherlands, we have established extensive experience and a solid reputation of producing cGMP peptides with batch to batch reproducibility combined with high yields and high purity profiles. We have extensive know-how and experience in both solution and solid-phase synthesis. In addition, we have a green method for the large-scale manufacturing of peptides in solution (GREEN CONTINUOUS LPPS).
Our peptide capabilities
- For synthesis manufacturing, we have stainless steel and glass-lined reactors ranging from 100 to 1500 liters
- Extensive know-how and experience in both LPPS & SPPS
- Patented green continuous method for large-scale manufacturing in solution (GREEN CONTINUOUS LPPS)
- For purification we use ion exchange chromatography and reverse-phase preparative HPLC columns up to 45 cm in diameter
- Final isolation is achieved using tray lyophilizers with a capacity up to 100 liters
Our green answer to peptide synthesis
We have developed a patented method for green and large scale manufacturing of peptides in a solution called Green Continuous Liquid Phase Peptide Synthesis (GREEN CONTINUOUS LPPS). GREEN CONTINUOUS LPPS combines the advantages of the classical solution-phase synthesis with the solid-phase approach, and is characterized by the fact that intermediates are not isolated. This enables a highly efficient synthesis method that is easy to scale up and yield products of reproducible high purity.
Our peptide products
| Key Product Development Parameters | Determined by | GREEN CONTINUOUS LPPS | LPPS | SPPS | |
| Time-to-market | Route development | Amenable to a generic protocol |   | – | |
| Scale-up & validation | Homogeneous synthesis | | / – | – | |
| Manufacturing effciency | Cycle times | No isolations/High throughput | | – | |
| Materials | Reagent excess minimized | | | – | |
| Minimal side-chain protection | / – | | – | ||
| No solid support | | | – | ||
| Product quality assurance | High purity | No insertion sequences | | – | |
| No deletion sequences | | | – | ||
| No side-chain reactions | | – | | ||
| Reproducibility | Reproducible isolations | n.a. | – | n.a. | |
| Reproducible supports | n.a. | n.a. | – | ||
| Enviromental demands | Organic waste streams | No Solvent changes | | – | |
| No organic washings | | | – |
